Haha, the intro with the VO was a nice touch. Pretty lighthearted and fun start to the game.
On the accessibility front, I'm running a Macbook Pro, so I don't play games at 1920 x 1080 (it's a 3024 x 1964 resolution screen that displays everything with double pixels at 1512 x 982). So putting the game window at 1920 x 1080 means it goes off the screen for me. You're not the only one to do that, and dw I get why you did – putting it in Fullscreen works. But, because escape is a button used for getting out of the tutorial or pausing the game, it also throws me out of fullscreen. So I found it difficult to engage with the tutorial early on.
Anyway, the gameplay itself was... interesting. Everything felt pretty "numbers go up", I wasn't really finding attacks that were orthogonal to what I could do previously. It would be cool to explore multi-attack, curving attacks, AOE, etc. I was mostly just picking the options with the biggest numbers and waiting to see if the game got fun.
Sorry for the harsh critique! I hope you enjoyed making the game. The wheelchair guy was a nice touch. If you decide to continue the game, my advice would be to throw in one orthogonal upgrade then give the game to 3 friends and watch them play. See what they're enjoying, and double down on that.