It plays really well but falls into simon-says and circle strafe for me where I just use super effective chemicals. Last run on medium difficulty surprisingly had only one recipe and no challenges so in total there was no space to push me out of comfort zone. Friendly fire is a great touch and there should be more shit like that. The boss battle is neat but it's way easier than any elite combat encounter.
It really makes me wish for a roguelike ripoff of Magicka with min maxing combinations of magic and interesting chemistry to figure out, weapon pickups and unique spells.