Gameboy games made without GBStudio have two advantages. First, they can focus all the memory and CPU on one single type of game, rather than making it friendly for a wide range of designers. Second, GBStudio creates layers of interpretation above the machine code so that users can write their own script--that is inherently slower, but again the trade off is worth it for the tool.
I'm not sure what you're trying to accomplish, but my recommendation is to ask in the GBStudio discord. You may also want to look at gud_graphics plugin for checking collision at tile location: https://github.com/mikeleisz/gud_gbs_plugins