Could you please elaborate your problem? There is no need to click multiple times and I added full-screen option. This game is mobile fortrait view friendly.
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I seem to have a similar problem: When in fullscreen, the upgrade "buttons" or "panels" are flickering, the "contracts" do too. On hovering, they look like a button that is pressed extremely fast, and so you have indeed click multiple times, until one click is successfull. It´s a bit hard to describe :)