Thanks for reaching out! I'm afraid I wouldn't know how to start doing this for video games - this was intended to be specific to Tabletop RPGs, which are more often formatted as PDFs.
That said, these two resources may be useful, and best of luck!
https://webaim.org/projects/screenreadersurvey10/ Screen Reader User Survey #10 Results
https://www.sarasoueidan.com/blog/testing-environment-setup/ Setting up a screen reader testing environment on your computer