Unfortunately the game isn't working for me at all anymore since the 12.0b update and I just picked up both additional dlc's that are out now. Continuous crashing even with a fresh install and new game.
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It seems like I found a fix to the issue, I was getting the exact same OSError: [Errno 9] Bad file descriptor as Kylel0519, same lines in the script as well. However when I moved it to a third location the game appears to be working again. EDIT: With the fresh install on a new hard drive it's still causing the same OSError: [Errno 9] Bad file descriptor. I tried moving the game folder and starting it without ITCH the game seems to run without issue.