If you mean the game on itch.io, posted by me, then yes it's safe. If you took the game elsewhere or from one of those bots that say "newest updated here", then no.
The game is very light, so you can easily run it on a VM, or just use sandboxie for extra safety.
-edit-
This is the Virustotal results: https://www.virustotal.com/gui/file/7c82c6db0252baba9f1fada24b53fb5813bcbab8a388... but most viruses work due to internet connection, which sandboxie can also block. My game doesn't try to access internet at all since I have no use for it, but it's always good to block it anyway just in case.
Finally, if you want to be extra cautious, I do plan on making a WebGL build at some point to be playable on the browser, so you can also wait for that if you so wish.