Make sure you have DXVK installed via Winetricks. That should be the only thing this program needs. Worst-case add vcrun2022 via Winetricks, but I don’t think that’s mandatory.
Woah that’s a crazy system. Well, WaMa uses Vulkan directly, so in honestly, DXVK shouldn’t be necessary either. It definitely doesn’t use Direct3D. Do you get any specific error message or just a “can’t run this file”?