Thank you for the feedback.
Regarding 1. the documentation says:
A few system functions are bound to various F-keys, accessible while holding the hotkey modifier which by default is the Control key. The hotkey modifier can be changed in the System Settings. These are the hotkeys: …
So it does mention that by default you hold the Control key and then use the F-keys. You can change Ctrl to be something else. This is important if you want to run a game that uses Ctrl+Fx for its own functionality.
Regarding 2. try running SETUP maybe? If it works in DOSBox it should work here.