Hello! I apologize for the late reply. I will be honest I'm not sure Twine to Ren'Py would be the best tool for this job, since it tends to work best for simpler + less complex projects. That said, if you do test it out on a larger project I would love to hear how it goes!
I am currently working on updating the tool to Python 3, but if there were any specific features you were looking forward to in an update I would be curious what you had in mind!