I was downloading around five other itchio games and none of them got flagged. I know Windows can ask you if you are sure to execute programs of unknown source, but that is not the same as both your browser and Windows Defender refusing to even downloading it because they detect it like a virus.
This depends on the game and which engine was used, as well as how the game was exported. I can guarantee you that this is not a virus, but if you still prefer to be safe, you should download it from Steam