Play to your strengths.
If your mostly a programmer, try to find a good source of ready made assets. If you have done a few games in a particular genre, try to stick to that genre.
If on the other hand, you do mostly Art and Story, Pick a genre and Game engine that focuses on that (e.x. a Visual Novel)
In either case, pick a game engine if you haven't already and experiment with it if you haven't already.