Hey Rskindred,
If you're on Android, I'd recommend disabling rollback, as accidental tapping on the screen can cause dialogue to do that.
However, if you're referring to quests not proceeding, some require certain progress with the main story or even other characters. You might also need certain stats with a character too.
You might also encounter a bug depending on the version you're on. We've been tackling a bunch of elements with the game recently in our House Keeping update(s), so some earlier game elements broke, but have either been fixed or is getting fixed as we move forward with each revision or version of the game.
If there's a particular quest you're on that doesn't seem to be budging, let me know what it is and I'll see if its something I can nudge you forward with or if it is a bug.
Appreciate you taking the time to swing by with your feedback!