itch.io

You should use the Itch application game launcher - 

https://itch.io/app

You should run all games in the Itch application game launcher while being sandboxed.  

Sandboxie is easy to use - 

https://sandboxie-plus.com/sandboxie/

and Itch has their own sandboxing utility - 

https://itch.io/docs/itch/using/sandbox.html

And of course you should always be running an up to date malware detector.

I do wish that people would take malware more seriously, gaming without full protection and running any unknown program can instantly disable and ruin an unprotected PC.