Hi! There’s one thing that needs to be done to make it run on MacOS for now:
In the Terminal app, type xattr -c "Blades of Exile.app" with the path where you downloaded Blades of Exile.
Have you done that yet?
If you slide into the community Discord, I can help figure this out if that’s not the issue. https://discord.gg/bHv2RCBQzX