Hi,
I don’t think it will cause any issues, since you can export the animation as sprite sheets and limit the number of columns and rows. I’m not sure what you plan to use it for, but for battlers, for example, it should work perfectly.
I’m just not sure about the overworld sprites. If you create them from 3D models, it won’t be correct, since they usually use front, left, right, and back, while PixelOver rotates the sprites clockwise, so it would be front, left, back, right with a 90° shift. I’m not sure if you can adjust this in RPG Maker, but if you’re not using 3D models or if you want to create a separate animation for each side, it’s not a problem.