Finally getting around to providing feedback:
Legibility
Clearly written, illustrated, and laid-out. I’d put the Player Information column on the left, but that’s just preference.
One potential concern is that the colored text may pose a challenge for GMs with colorblindness. I suggest pairing the color-coding with bold (for locations), italics (for NPCs), and underline or capitalization (for infested items).
Modularity
Plenty of good hooks that lead to an evergreen adventure location that can I can see fitting in almost any space sandbox.
Theme Usage
Turning A Color Out Of Space into a dungeon crawl, and seems to do a good job of adapting the chromatic horror of the story into something interactive.
Runnability
It seems all the necessary fictional and gameplay elements are present. Despite being system-agnostic, you even made sure to include simple yet useful mechanics for the threat.
X-Factor
This is my platonic idea of a Sci-Fi One-Shot Jam submission. You knocked it out of the park with a adaptation to a story I enjoy.