Ok, just to get this out of the way, I really love tower defense games, and I really sucked at this one. Running the windows native version, so no excuses. I'm just garbage at keeping a beat. That being said, this is still one of my top games so far.
As others have said, the mechanic of timing the button presses to the patterns, while engaging (and beyond me, apparently) does pull your eyes away from the action. Playing on a large display makes that even worse. I would love to see this explored more. The towers already provide some feedback, so perhaps that could evolve to help draw the player's focus back up into the action, or maybe the buildings along the path also animate in some way to help communicate the patterns.
This concept needs strong audio, which it has all day. The graphics are great. Honestly, it felt more like I was playing a demo for an upcoming release than a game jam submission. Amazing work.