I've been playing through the game over and over because my browser keeps deleting my save and actually it's pretty fun.
I've been finding that I need to make the trip from Talos to Sanorini aided by the resources from Laurion about three times before I can start heading directly for Santorini right after leaving Talos. Once you can do that, there's no reason to visit Laurion again except to complete blue actions there, because Santorini has enough fuel to fill up your supply and then some.