Howdy!
A full game guide is planned when the game hits 1.0!
Also, thank you for reporting that bug. I'll look into it this week!
If sufficiently game-breaking, then yes, they'll be implemented as soon as possible.
Speaking of which--Just pushed a bug-fix for the game which fixes the mutation removal process clearing your blocked mutations. Go through the mutation remover to fix your save and prevent blocked mutations showing up again.