Hi,
There are 2 types:
- stat-altering like cha/int/dex, money, stamina, time - those cannot be undone, you'll have to load back a save before enabling them, or start a new game;
- non-stat-altering like less flies, 4-eyes not coming, she doesn't wake up - those are only active until you quit the game, so reopening the game will disable them.
Hope this helps,
Cheers