There are some great ideas here. I love the element screen and how they intersect to form other elements. Really cool take on crafting.
I think the player interaction and reactivity could be improved. What is the reward for the player? What experience do you want the player to have? Asking because I'm not sure if it's supposed to feel like sudoku puzzles or opening a chest in Vampire Survivors. Overall I get more of a sudoku feeling of just going through the logical motions until my grid is complete. It didn't have a lot of excitement for me.
The animations for collision, sythesis and energize should be shorter and skippable. Running out of energy and having to wait for the re-energize was very demotivating. I might also suggest always having the buttons for the different modes available. I almost misclicked the wrong process a few times which would have lead to catastrophic energy loss for no progress.
Still, one of the more interesting jam games I've played this year. Good system design.