I think your game could be awarded with epilepsy warning at the beginning of the game :D
Flying all the way to the start of the game can cause something like this.
My coordination is fine. The last time I felt something like this was in VR, but now I feel like I'm seasick from your game :D I don't want to say anything bad, everything plays very juicy! The biggest impact was the shaking of the screen from the shot.
The controls in the game are very responsive, I liked stepping on enemies and shooting. I didn't expect to see the Mario mechanics with stomping opponents, but it is very appropriate here!
The visual style is very cool, I like the change of palettes. In my opinion, it would be cool to lengthen the sections with one palette a little, so that the change is not so frequent. And you could also add some environmental effects, unique enemies to your palette, then a certain color scheme would evoke their own emotions in players, which would be quite interesting. Again, this is my opinion, you have your own vision, it is very cool!