Are the runes completely random every phase or is there a way to figure out which do what before clicking them? Seeing as you can ruin a run with with 4 unlucky clicks
The rune colors are set, they change twice during a run (so 3 sets per run). For example the first demon always has red & blue, blue & green then blue & yellow (at least from what I remember). Annoyingly the runes that come onto the screen are random though, so getting the required time for 100% is purely RNG.