I think that Return to Origin did more than just return me to the beginning of my prestige run. My total humans have returned to where I was before my last ascension.
No worries. I left the PC running while at work with the autos on and an autoclicker for something that has no auto and I am back up to 20 billion humans.
Something that might be nice would be something that shows how many super humans you get for x humans without ascending. Or even once you have ascended. It only shows the number of humans that it costs for your next super human ascension, not the cost of the next (and all subsequent) super humans.
Then again, I imagine that this won't be that much of an issue once Universe works correctly and when/if there is a new prestige layer.