Haven't been able to finish yet as it's unexpectedly punishing, so my comment should be taken accordingly:
Gameplay: I love a good complex mechanic system, so I love what you have going on here. Really, the only issues I'd raise are:
1. The game isn't super upfront about its mechanics (knowing that it's based on F&H doesn't help if I haven't played that, and while there is a very well-written tutorial in your items, the game does not tell you that you have that item so you might easily not notice- I died twice before I realized I had started with a key item from the get go and that it contained a tutorial; I wouldn't want a forced tutorial but a clearer indication that you have the book and/or some early NPC/item inspection hints warning you that soul and curse matter as much as flesh would help
2. The balance on how fast you lose soul vs the actual availability of soul restoration items might need some tweaking, it feels a little too easy to run out of soul too soon right now, which wouldn't be as big a deal if not for:
3. Lack of save availability. I assume it exists later in the game based on the "continue" option, but unless I missed something right now it's quite possible to die and lose a decent amount of progress without ever getting to save.
Don't mistake the length of that critique for thinking I felt negatively about gameplay overall, I like what you're doing here overall!
Story: Can't say as much here since I didn't meet many NPCs or other story sources thus far. Your lore seems quite interesting, but it might help to have just a little more context (even if it's just on how much context the protagonist doesn't have, if that makes sense- what does she understand of the situation, is more what i mean) in the intro scene. On a related note, being able to skip the intro would be nice in case of death before saving- was that possible? I didn't notice if so.
Presentation: the uncanniness of the 3D-ish models moving in such a rigid 2D way calls to mind stop motion, and I think it just adds to the unsettling atmosphere. Great example of turning limitations into features, I'd say. Love it.
Enjoyed it enough that I'll be back and possibly revise my comments once I get further!