"Uni 2" is an extremely long ways away as it sits at the end of our game roadmap and will have no connection to Chelsea and her story. It will take place in a different city and will be in the same fictional country, but will not be a sequel to the events of Uni. Because of this the game's title will not be "Uni 2" and we already have a few different working titles for it.
As for Matt, you'll more than likely get a few tidbits of information that explain how he turned out this way, but if you're on his routelock you've already accepted your position under him and will not have a path to get out from his route from there on since you've been given several ways out prior to his routelock.
Nathan will not have any NTR scenes as those scenes come from route conflicts. Since you have to not be dating anyone else to start dating Nathan he won't have any of those conflict scenes.
Then you'll really enjoy the next update when it comes to Itch since it expands passed Kate's routelock further.
Every little bit helps! The more budget we have the more we can get done, thank you!