That's NTR and gangbang and rape and drugged
I don't want to sound like a nerd, but just the fucking alone (with a dick larger then MC dick, which means the dick is very probably too big for her) would not only hurt her but too damages the cervix, which could destroy her probability of getting pregnant or something, and then the countless "creampies" which would be definitely too much for her would damage her womb and everything, because it would stretch it from the inside and everything and they didn't even care if she gets pregnant or not, and from what I saw, her only brake would be (if she got any breaks) the time she sleeps and the amount of drugs like "PP" damages her body too, which could kill her
Of course, they can add NTR (cheating on bf/gf/husband/wife/ person you are in a relationship with)but in my opinion that's too far...
I think I sound like a nerd in Anatomy and Biology, I know -_- ...
Don't worry about sounding like a nerd (I am one too). As far as I've understood, this game was meant to border on the more extreme "tastes" and all of what you've mentioned are themes that aren't at all that uncommon in hentai and other pornographic fiction. They are themes that I for one can be interested in (other than ntr actually) when knowing it's fiction. When I think about it happening irl however I get truly naucious.