Hey, sorry about that! Could you try running it through a terminal window (like command prompt) with something like VVVVVV.exe -renderer direct3d and see if that works?
If not, could you try the others on this page https://wiki.libsdl.org/SDL2/SDL_HINT_RENDER_DRIVER and see if any DOES work and report back? We made a last-minute change to the renderer and I wonder if that causes a bug on some machines.