Fun concept.
Some issues I have noticed:
When you hire a trader, the name still stays in the list. So you can actually hire the same multiple times. I find it a bit odd that you can't change the parameters you once gave a trader. I don't understand the differences between traders regarding regional and remote, and their traits like Quality Control.
When you manually sell and look for the best price tag. You have to make sure to sell the bottom items first otherwise your farmers might harvest and rearrange the inventory list thus leaving you sell something else.
Farm orders where not clear to me how they work. How do I fulfill the order? So instead of me having to ship grapes I received 7 bushels each week indefinitely (already counting -14 weeks)?
Rice? Mushrooms?
At times you can't buy new plots of land even when not maxed out? Had to reload. And when I had 20 plots (out of 22) and reloaded I then only had 16. Somebody stole my land.
Reloading I still had the research for two orders but the button was not active. Instead it said that I first have to research the feature. When I researched the third option I was able to access the feature again.
Didn't figure out how market manipulation would work.