The game could appeal to more than just furries. There are human and demon characters, and all the fun BDSM and kink stuff has universal appeal.
You could even set the dynamic NPC generation in such a way that all dynamically generated NPCs are anything but anthro animal folks. You can't change the story NPCs like Dr Quinn, Kidlat, Alex, and etc. without, like, modding it, specifically. But yeah, you could certainly go about making for a furry-free experience, if so desired.
Some people might appreciate horny furry shenanigans without necessarily being furry themselves.
There's a very good chance that a lot of us are furries. But some non-furries are here, too. Just because there's a huge furry focus doesn't exclude non-furries, or preclude little appeal to non-furs. c: