Amazing art and sound design! It was a good experience all together with a few minor complications.
The toggle click UI behavior took some time to get used to, and I'm not sure I was completely comfortable with it at the end.
It was great fun trying to pick apart how the mechanics work, but as we discussed, it may not be appealing to a large population of gamers. Consider having a codex or option to enable tooltips.
For the Loaded Dice, mentioning that it effects immediately and some type of audio/visual feedback would be very helpful.
The core combat mechanic requires mashing a button in a way that can't really be replaced by a Press & Hold control. Just be aware that this excludes a population of gamers that have motor control issues or are prone to repetitive stress injuries.
The game does have a possibility to lock the player out of further meaningful gameplay, usually this would trigger a game over screen and send them back to the title
During the stream we had a good discussion about how a player could dead end their run. If the end of a game is expected, the game over screen would prevent the user from thinking the run is salvageable. If it was salvageable, consider that the resources in the game are finite.