I loved the game idea and card design! I thing both the "Expedition" and "Side Effects Includes" themes are well covered.
One thing I'd explore more is how to add more risk/reward into the actions. For instance, most of the times ending the turn and just keep drawing cards doesn't give the player any penalty. It could be something like: "take the card, but lose one HP" or "every time you skip your turn, an extra enemy appear on the field" - anything that would make the player thing "is this action worth it now?".
Also, each turn the player can do too many things at once. In many tabletop card games you need to pick one (or a few) actions from several possible. Take "Ticket to Ride" for example: you can either draw new cards and risk letting your opponent block your train in the meantime, or you can build a train but eventually run out of cards in the worst possible moment.