GD4 is an HTML file, which means that it should be able to run on any browser. The issue is just that GD4 is extremely poorly optimized, and therefore it might not be able to run on slower computers (like a Chromebook).
I already compressed the MP3 files like a year ago but that just reduces the size of the HTML file, not how smoothly it runs.
I could probably make it run smoother by reworking the code for buttons so that button clones that aren't in use will be deleted, but that would take a considerable amount of effort which I currently don't feel like doing at the moment.