Yes! The choices do matter. For example, being human gives certain options with certain characters, and being a werewolf has some of its own issues if you explore the many options over the first several days. Some of the choices have subtle differences, others are more distinct.
Additionally, each job (there are 9) and dating route (there are 6 planned) will also have unique impacts on the climax of the story. Lots of stuff is planned out and the choices, though they won’t affect the main course of the story, will affect how it plays out and what details you see.