I'm left handed and only use mouse with my left hand. The controls make it impossible for me to play. I generally expect any WASD game with no rebinding controls to at least support Arrow keys.
Peter doesn't have that problem and says that reload (which is pinky finger in a terrible location for me) is also hard for them and we agree that right mouse button would be a better keybind for reloading. Peter says it's fun, but I can't confirm/deny since it's unplayable for me.