This reminds me of the NWN module "Almraiven" (one of my favourites) and I was in fact really thinking of how to make something similar in RPG maker, well, here we are.
If it writes the current hour of the day to an in-game variable you can specify e.g. Variable #5 then yes. This works by reading the current time from a variable so any plugin that uses variables is in theory compatible :)
