I remember hearing from one game dev that some of their Android users had trouble installing the game when the APK went beyond 2GB, and in the end they split the Android version of the game into two games (it was a linear story game, so that was possible for them, as the second part just continued where the story left in the first part). Another game shipped an installer with the APK, which itself then downloaded the actual game files, though because of that the game loading is annoyingly slow. Hope you don’t run into such issues.
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Tried a quick googling and there seem to be quite a few people complain about not being able to install APKs >2GB. May I suggest building an artificially inflated APK in your free time and testing? Probably better to know early if this is gonna be a problem in a not so distant future instead of the last second. I don’t know if you already do so, but when building for Android, since the screens are generally small, it might be fine to reduce asset quality a bit to save space, on the small screen it could still look pretty much the same