Queen's Brothel requires your web browser to be able to use SharedArrayBuffer and so far I've only noticed that Safari can not do it. Chrome and Firefox work.
There's a thread on a SharedArrayBuffer flag and it's side effects on both the game's itch page, and the downloadable version of the HTML5 game, it's 2 years old so it might be out of date, and I assume you probably already saw it, but I'll link it just in case you haven't:
https://itch.io/t/2025776/experimental-sharedarraybuffer-support