Pretty much every persistent item is way too much.
The moment I find any enemy where they put an eggplant or spiral on your side you're just done with the run.
The only thing that isn't too much is bovine milk cause you can at least manage it well to keep going but anyone with Eggplant or Spirals (or hell both. Both should never be a thing.) is pretty much the end of the run. You can't get anything in your cauldron to do anything and they just keep moving forward while you're crippled forever.
persistent things just don't work in the quantity that they are in currently.
The only time I've ever gotten past one is a single run where I had the shrinking reagent and even then it was barely possible and took forever.
Other than that the game's really good and hope you keep going with it. (Seriously tone down the persistent reagents they're both too plentiful and mixing them makes it far FAR worse.)