I've been playing this a few times and part of me intends to try a run in which I lose no clothing ( Can be very difficult since one missed jump means replaying the first half again ). I mostly use the Delete Save File feature to immediately start the game again as the lack of a New Game / Continue option select does make things tricky. Though I may see if Delete Save File affects more than just starting the game from scratch.
I think it might help in a later update to tone back on the Eyeball-Delinquents as the amount that chase after you can really be annoying to deal with in some cases. Something I learned to deal with them is that if any attempted to bump into Molly while she's on the ground, they'll be bounced back while Molly stays put. With this in mind you could potentially increase the knockback the Eyeball-Delinquents receive and force them to stop after the bounce. This would avoid being ping ponged around by 7 of them without much to do.