Sorry for the delay...life's getting crazy. Here's a pretty basic spreadsheet I came up with to track modifiers and effects. It's working pretty well so far!
I'm just starting the 5th floor, so strong enemies are still at 25 damage. I'm taking them out with one shot. Floors 6 and up look like they'll start being much more balanced and more of a challenge. I'm sure higher floors will make me have to slow down and strategize more. I'll report back when I get further. Apologies for taking so long on this playthrough!