I'm sorry to hear that! Could you give me some more info? I'd like to fix this bug as it's pretty game breaking.
What browser and browser version are you using?
Does it look like the inventory is working? Does it put the white highlight box on items when you click on them or press the 1-5 keys?
Does it look like the ground highlighting is working when you walk around the dirt tiles?
Does the E key work for other stuff like opening the Ship UI and the Shop UI when you press it near the ship or shop?
Do the animations play like when you press E with the hoe equipped in slot 1? Or does it just do nothing when you press the E key with that item equipped?