Ran this recently - I'm a new Warden and this was my second time running a Mothership game and first time running a pamphlet adventure. It went really well!
The setting is so cool and the whole adventure is easy to run once you get going. The 'rooms flipping states' as the infestation progresses is super fun.
I changed a couple of things - mainly added a MedBay in the Lab, added an Airlock in the Armoury, and made pre-gen characters with roles on the sub (medic, navigator, assistant engineer, android underwater mining bot, etc.) with submarine-specific loadouts (changed things like Vaccsuit becomes SCUBAsuit).
Would love to run this again.