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How long is a piece of string? There's no way to answer the question without knowing more about the game itself. That said:

  • Faking 2D with 3D is a trap, because you get all the difficulties of working with 3D with none of the benefits.
  • Android supports 3D by definition -- its very specification requires hardware with OpenGL support. On other platforms it's not as guaranteed as people think.

Hopefully this will help make a decision. Cheers.