I don't use avast anitvirus, and Windows Defender doesn't seem to have an issue with the game. I'll try reinstalling from itch.io again.
Idk if it helps at all, but the past couple of times I've booted up the game, even after reinstalling, it didn't install the separate package of assets, or whatever. I remember when I booted up the game for the first time it had a progress bar at the bottom while it did something with it's assets, but that hasn't happened since then, even after moving all of the data under AppData.