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I think perhaps the difficulty early game could be adjusted a bit if this is going the roguelite direction in the end

It's funny because I culled the amount of enemies that spawn in this build but it might've not been enough. I'll fiddle with the numbers again.

I would try [the slowdown], put out a test-build and see how people respond to it. 

I'll try implementing it later today, I can send you a test build if I think it seems promising enough to test.

 I think maybe adding a "filler enemy" something, more or less not that dangerous and slow could be good to fill out early rooms before ramping up the difficulty.  Otherwise: stationary turret enemies, enemies that change their chemical setup, 

Stationary enemies are a cool idea, I might steal that one. Enemies that change their weaknesses are already planned and are reserved for later levels, it sounds like too much for the first biome.

I want a rifle-version of the gun.

What do you mean by "rifle"? That could range from a Garand-esque single fire weapon to a machinegun. Either way, I don't plan to add any more conventional guns since they would massively overlap with the pistol secondary functionality-wise. My ideas for new weapons are less conventional, among them are: a firehose primary; gas grenade secondaries; a shield secondary that absorbs damage; a utility that spawns drones that damage enemies and heal you.