On my Q2, QPro and Q3, I'm able to start 2D apps like messenger or my file manager with the 3 methods. Open Next to, need a free place next to QGO. Do you have the problem with all the 2D apps ?
If you have the QGO premium extension, you can run ADB shell commands directly from the ADB Shell terminal. If you get the Quest IP, you should be able to connect via the IP from the PC. Anyway, QGO don't need USB connection since a long time now