I don't yet have as much idea how you want to organise diseases and their transmission, but an idea of mine would be to increase the infection rate in the toilets if there are people there.
Right now it’s very simple, but I’m going to redo the way it transmits
the first infection type will probably be airborne, but you could imagine something like a waterborne infection would spread more in toilets. this could be combined with using ability points to do things like flood it