finished the game around 3 days ago, came back to say it's really good again! looking back on it i'd say losing weapons isn't such a big deal, just didn't realize their appearance rate was tied to game progress, and that it becomes much harder to die once you've got plenty of warp orbs, hp, and good weapons.
my only real complaint would be that the encounter with the "useless" npc is very rare and it took me quite some time to get the hand drill, that i didn't know it would lead to that and that by that point you've already seen almost all the encounters and whatnot didn't help. the hanuman enemies are very dodgy and tanky as well, though i can see that being on purpose to provide a challenge when you've got the best equips.
once again, this is an incredible game, may it be complete soon!